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TTF-1/Napsin A detection reagent (Immunohistochemical)

TTF-1/Napsin A detection reagent (Immunohistochemical) is mainly used to qualitatively identify TTF-1 and Napsin A proteins. Using immunohistochemical dual staining detection and multiple antibody combination technology, there are detected two antigen targets at the same time on the same sample tissue section by one staining process.

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Specification

Model Number	Specification
SD8101	1mL/pcs; 3mL/pcs; 7/pcs

This antibody is used with Immune Chromogenic Reagent (Dual Staining I) (SD8001)

Clone: Mym1-TTF1 + BP6083

More Info

TTF-1 is expressed in the nucleus of thyroid follicular epithelium and alveolar epithelial cells. It is the primary marker for the differential diagnosis of lung adenocarcinoma. TTF-1 is expressed in more than 70% of non-mucinous adenocarcinoma subtypes, small cell lung cancer, a small portion of undifferentiated large cell lung cancer and atypical carcinoids, a small number of typical carcinoids. In addition, a small number of lung squamous cell carcinomas show TTF-1 positive expression.

Napsin A is expressed in normal alveolar type II epithelial cells and proximal and distal renal tubules. Napsin A shows positive in 80%～90% of lung adenocarcinomas. But Napsin A shows negative expression in almost all lung squamous cell carcinomas. The sensitivity and specificity of Napsin A are better than TTF-1. TTF-1/Napsin A combined primary antibody show higher sensitivity.

In non-small cell lung cancer, positive expression of TTF-1 and negative expression of NapsinA can occur in some large cell neuroendocrine carcinoma similar to adenocarcinoma. TTF-1/Napsin A combined primary antibody can effectively identify these tumor diseases.