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Thyroid Peroxidase(TPO)

Thyroid peroxidase (TPO) is an enzyme expressed in the thyroid. TPO oxidizes the iodine ion to form an iodine atom, which binds to the thyroglobulin's tyrosine residues to produce thyroxine (T4) and triiodothyronine (T3). The expression of TPO gene is regulated by thyroid stimulating hormone. In the normal thyroid, TPO shows diffuse in all follicular cells with granular cytoplasmic staining. The expression level of TPO in thyroid cancer is lower than that of normal thyroid and benign thyroid tumors.

Staining Tissue

  • As Figure shows:

Lymphocytic thyroiditis tissue stained with TPO

Specification

CODE

 WORKING  SOLUTION

CONCENTRATED SOLUTION

CTR-0161

SPECIFICATION

1ml

3ml

6ml

0.1ml

0.2ml

More Info

Clone:  EP159

Source: Rabbit

Localization: Cytoplasm

Pretreatment:  Thermal remediation

Applicable tissue: Paraffin section

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