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Lymphoma Pathology

2021-03-04

By snt_manager

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Hodgkin disease results in enlargement of the lymph nodes and spleen. Whereas Hodgkin disease generally has a high cure rate, non-Hodgkin lymphomas are often more difficult to treat. Burkitt lymphoma is a non-Hodgkin type. 

It is known that CD3 and CD20 are homogenously expressed in T lineage and B lineage lymphoma, respectively. CD20 and CD3 are commonly used as specific markers of B and T lineage lymphomas, respectively.

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Celnovte CD20(C4A11)-Lymphoma-200×

Pathological examination is the main means of diagnosis of lymphoma. The pathological diagnosis of lymphoma requires comprehensive application of morphology, immunohistochemistry, genetics and molecular biology techniques, and flow cytometry, etc.

  • Morphology: It is very important in the pathological diagnosis of lymphoma. Different types of lymphoma have characteristic and diagnostic morphological features.
  • IHC: It can be used to identify immunophenotype of lymphoma cells, such as B or T/NK cells, tumor cell differentiation and maturity, etc. By combining with related IHC markers, differential diagnosis of different pathological subtypes can be performed.

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Celnovte CD10(C6D1)-Lymphoma-200×

Celnovte TDT(C2C8)-Lymphoma-200×

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  • FISH (fluorescence in situ hybridization) detection technology：It can find specific chromosomal breaks, translocations, amplifications, etc., which have guiding significance for the auxiliary diagnosis of specific chromosomal abnormalities related lymphomas, such as Burkitt lymphoma t(8;14) translocations, follicular lymphoma t(14;18) translocation, etc.

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