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HER2 positive cancer refers to a type of cancer that tests positive for the human epidermal growth factor receptor 2 (HER2) protein. This receptor is part of a network that regulates cell growth and division. When there is an overexpression of HER2, it leads to more aggressive tumor growth and a higher likelihood of metastasis.
Progesterone receptors (PR) play a role, in controlling reproductive functions and are essential for maintaining reproductive health by responding to progesterone effects in the body. They function by interacting with the progesterone hormone to trigger responses necessary for reproduction.
ER positive breast cancer is characterized by the presence of estrogen receptors on the surface of the tumor cells. In this context, estrogen plays a significant role in promoting the growth of these cancer cells.
HER2, or Human Epidermal growth factor Receptor 2, is a protein that plays a critical role in regulating cell growth and division. It is a member of the HER family of receptors, which are found on the surface of cells. In the context of breast cancer, HER2 is noteworthy due to its role as an oncogene.
Immunohistochemistry (IHC) staining involves a procedure that may encounter obstacles. It's vital to address these issues adeptly to ensure outcomes and preserve the authenticity of your samples. Three common challenges in IHC staining are staining results, excessive background noise, and unspecific staining patterns.
Staining tissues with IHC is a method used in pathology to reveal antigens in tissue samples. This involves a series of steps including preparing the tissue, retrieving the antigen, blocking nonspecific binding, and applying primary antibodies for visualization.
Multiplex Immunohistochemical Kits (mIHC) are invaluable in immunology studies as they enable the simultaneous detection of multiple biomarkers in a single tissue sample.
IHC can identify different diseases and in particular cancer. With its ability to detect target antigens in tissue samples, it is the perfect tool to study cellular elements and their interactions.
Advanced machines known as immunohistochemistry staining devices have been developed to assist with staining tissue samples using methods efficiently and effectively by automating stages of the process like deparaffinization and antigen retrieval, among others to increase productivity in labs significantly.