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ER positive breast cancer is characterized by the presence of estrogen receptors on the surface of the tumor cells. In this context, estrogen plays a significant role in promoting the growth of these cancer cells.
HER2, or Human Epidermal growth factor Receptor 2, is a protein that plays a critical role in regulating cell growth and division. It is a member of the HER family of receptors, which are found on the surface of cells. In the context of breast cancer, HER2 is noteworthy due to its role as an oncogene.
Immunohistochemistry (IHC) staining involves a procedure that may encounter obstacles. It's vital to address these issues adeptly to ensure outcomes and preserve the authenticity of your samples. Three common challenges in IHC staining are staining results, excessive background noise, and unspecific staining patterns.
Staining tissues with IHC is a method used in pathology to reveal antigens in tissue samples. This involves a series of steps including preparing the tissue, retrieving the antigen, blocking nonspecific binding, and applying primary antibodies for visualization.
Multiplex Immunohistochemical Kits (mIHC) are invaluable in immunology studies as they enable the simultaneous detection of multiple biomarkers in a single tissue sample.
IHC can identify different diseases and in particular cancer. With its ability to detect target antigens in tissue samples, it is the perfect tool to study cellular elements and their interactions.
Advanced machines known as immunohistochemistry staining devices have been developed to assist with staining tissue samples using methods efficiently and effectively by automating stages of the process like deparaffinization and antigen retrieval, among others to increase productivity in labs significantly.
HER2 also known as human epidermal growth factor receptor is a protein that plays a role, in the development and survival of types of breast cancer cells.
The main advantage of the Multiplex Immunohistochemical is an advanced technology that allows assessing the same tissue section with the usage of multiple biomarkers simultaneously.