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Cervical cancer is a significant global health concern, but early detection and diagnosis can dramatically improve treatment outcomes. The P16/Ki-67 dual staining technique has emerged as a powerful tool in this fight, offering valuable insights into the cellular processes underlying cervical cancer development.
Biomarkers have become pivotal in histopathology, offering insights into cellular processes and disease states. p16 and Ki-67 are two such biomarkers that have gained attention for their roles in cell cycle regulation and proliferation.
Periodic Acid-Schiff (PAS) staining is a widely used histological technique that allows for the identification and visualization of certain carbohydrates, such as glycogen and mucopolysaccharides, within tissue samples.
p16 and Ki-67 are pivotal biomarkers for cervical precancer detection, serving as important indicators of cell cycle regulation and proliferation. The p16 protein is typically expressed in response to the activation of oncogenes such as HPV, while Ki-67 reflects cellular growth.