The basic structure of the immunoglobulin molecule consists of two identical heavy chains ( γ、μ、α、δ、ε) and two identical light chains (κorλ). Any heavy chain can be combined with a light chain, but the two light chains are of the same type on the immunoglobulin molecule. The ratio of the κ light chain and the λ light chain between the Ig and subunit is different. Additionally the ratio of the κ light chain and the λ light chain of B-cell is about 2:1 in the polyclonal groups.But a single B cell expresses only the κchain or the λ chain, and never expresses both.Usually most of the κ and λ chains bind to heavy-chain immunoglobulins. However, in normal individuals, there are low levels of free light chains in the serum. So,the presence of cells with a mixture of κchains and λ chains indicates the presence of polyclonal group and B-cell reactive or non-tumor proliferation.
Tonsil tissue stained with Lambda Light Chain λ
The basic structure of the immunoglobulin molecule consists of two identical heavy chains ( γ、μ、α、δ、ε) and two identical light chains (κorλ). Any heavy chain can be combined with a light chain, but the two light chains are of the same type on the immunoglobulin molecule. The ratio of the κ light chain and the λ light chain between the Ig and subunit is different. Additionally the ratio of the κ light chain and the λ light chain of B-cell is about 2:1 in the polyclonal groups.But a single B cell expresses only the κchain or the λ chain, and never expresses both.Usually most of the κ and λ chains bind to heavy-chain immunoglobulins. However, in normal individuals, there are low levels of free light chains in the serum. So,the presence of cells with a mixture of κchains and λ chains indicates the presence of polyclonal group and B-cell reactive or non-tumor proliferation.
Product Name | Lambda Light Chain(SHL53),MMab |
Catalog No. | CLM-0010 |
Intended Use | IVD, RUO |
Species Reactivity | Human; others not tested |
Cellular Localization | Cytoplasm / Nucleus |
Antibody Type | Mouse Monoclonal |
Clone | SHL53 |
Format and Volume | Ready-to-use: 1mL, 3mL, 6mL Concentrated: 0.1mL, 0.2mL and 1mL |
IVD Datasheet (IFU) | ↕️ Download |
RUO Datasheet (IFU) | ↕️ Download |
SDS sheet | check with sales |
Store at 2~8°C. Avoid freezing.
Maintain temperature below room temperature during transport, ensuring it does not exceed one week.