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HBME-1

HBME-1 is mainly distributed in mesothelial cells and not expressed in other glandular epithelium. It has a certain role in distinguishing mesothelioma from adenocarcinoma. The positive part of this antibody in malignant mesothelioma is mostly cell membrane. In other adenocarcinomas, this antibody is mostly cytoplasmic positive, which need to pay attention to identify during diagnosis. The antibody is abnormal expression in thyroid cancer, showing strong positive staining of the periapical membrane, which highlights the small foci of cancer in benign thyroid tissue. The antibody can be used in combination with other antibodies (CK19, CD56 and Galectin-3) for the differential diagnosis of benign and malignant thyroid cancer.